Population
Isolated ferret papillary muscles
Comparison
Metabolic blockade followed by reactivation of… vs Baseline/control levels prior to metabolic…
Design
Preclinical
Authors
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Hypothesis-generating for Na-Ca exchange inhibition in ischemia-reperfusion injury; leaves open translation to human cardioprotection strategies.
In isolated ferret ventricular muscle, elevated intracellular calcium during reactivation of oxidative metabolism directly impairs the recovery of mechanical function.
Smith et al. (1988) studied this question.
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