Key result
Decreased carotid strain (HR 0.425; 95% CI 0.223-0.811) and strain rate (HR 0.001; 95% CI 0.000-0.072) were independent predictors of cardiovascular events in patients with hypertension.
Why the study?
The prognostic effects of carotid strain and strain rate in patients with hypertension needed investigation.
Do carotid strain and strain rate predict major cardiovascular events in patients with hypertension?
Observational (n=120)
Do carotid strain and strain rate predict major cardiovascular events in patients with hypertension?
Decreased carotid strain and strain rate measured by speckle tracking ultrasound independently predict major cardiovascular events in patients with hypertension.
May aid risk stratification in hypertension; extends strain imaging data but leaves open prospective validation.
BACKGROUND: We aim to investigate prognostic effects of carotid strain (CS) and strain rate (CSR) in hypertension. METHODS: We prospectively recruited 120 patients being treated for hypertension (65.8 ± 11.8 years, 58% male) in this observational study. Peak circumferential CS and peak CSR after ejection were identified using two-dimensional speckle tracking ultrasound. Major cardiovascular events were any admission for stroke, acute coronary syndrome, and heart failure. RESULTS: After a mean follow-up period of 63.6 ± 14.5 months, 14 (12%) patients had cardiovascular events. Age (75.3 ± 9.2 vs 64.6 ± 11.6 years; p = 0.001), systolic blood pressure (131.8 ± 15.5 vs 143.1 ± 16.6 mm Hg; p = 0.021), diastolic blood pressure (74.6 ±11.4 vs 82.1 ± 12.2 mm Hg; p = 0.039), use of diuretics (71 vs 92%; p = 0.014), carotid CS (2.17 ± 1.02 vs 3.28 ± 1.14 %; p = 0.001), and CSR (.28 ± .17 vs .51 ± .18 1/s; p < 0.001) were significantly different between the patients who did and did not reach the end-points. Multivariate Cox regression analysis controlling for age, systolic blood pressure, diastolic blood pressure, and use of diuretics showed that CS (HR .425, 95%CI .223-.811, p = 0.009) and CSR (HR .001, 95%CI .000-.072, p = 0.001) were independent predictors for cardiovascular events. CONCLUSION: In conclusions, decreased CS and CSR were associated with cardiovascular events in hypertension.
No takes yet. Share an insight, caveat, or question.
Tsai et al. (2021) conducted an observational in Hypertension (n=120). Carotid strain (CS) and strain rate (CSR) was evaluated on Major cardiovascular events (any admission for stroke, acute coronary syndrome, and heart failure) (HR 0.425, 95% CI 0.223-0.811, p=0.009). Decreased carotid strain (HR 0.425; 95% CI 0.223-0.811) and strain rate (HR 0.001; 95% CI 0.000-0.072) were independent predictors of cardiovascular events in patients with hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: