Population
Mutant mice lacking GIRK2 (GIRK2 -/-), weaver mutant mice (wv/wv), wv/- mice, and wild-type mice
Comparison
Genetic knockout of GIRK2 vs Wild-type mice and wv/wv mutant mice
Design
Preclinical
Authors
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Animal data implicate GIRK2 gain-of-function in seizures; leaves open relevance to human channelopathies or therapies.
The study demonstrates that the weaver phenotype is caused by a gain-of-function mutation in GIRK2, and that GIRK channels are crucial mediators of neuronal excitability.
Signorini et al. (1997) studied this question.
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