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December 31, 2015Egyptian Journal of Veterinary ScienceOpen Access

Fifteen FMDV serotype SAT2 isolates from the 2012 Egyptian outbreak were found to be antigenically closely related to the vaccine strain.

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Population

Cattle and buffaloes affected by foot and mouth disease virus outbreaks in Egypt, yielding 15 FMDV isolates.

Design

Preclinical

Key result

Fifteen FMDV serotype SAT2 isolates from the 2012 Egyptian outbreak were found to be antigenically closely related to the vaccine strain.

Discussion

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Overview

Supports vaccine strain selection for Egyptian SAT2 outbreaks; leaves open need for ongoing antigenic surveillance in veterinary settings.

Study Design

Type

Observational (n=15)

Multicenter

Yes

Structured PICO

P
Population
15 FMDV isolates from cattle tongue epithelial tissue samples collected during the 2012 outbreak in Egypt.
E
Exposure
Genetic and antigenic characterization (virus isolation, RT-PCR, real-time RT-PCR, virus neutralization test, ELISA) to monitor circulating virus strain and match with vaccine strain.
O
Outcome
Antigenic matching of FMD virus isolates and vaccine strain (r-value)surrogate

The 2012 FMDV SAT2 outbreak isolates in Egypt were antigenically closely related to the existing vaccine strain, indicating the vaccine was appropriate.

Cite This Study

A 2015 study conducted an observational in Foot-and-Mouth disease virus (FMDV) (n=15). Vaccine matching tests was evaluated on Antigenic matching of FMD virus isolates and vaccine strain (r-value). Fifteen FMDV serotype SAT2 isolates from the 2012 Egyptian outbreak were found to be antigenically closely related to the vaccine strain.

synapsesocial.com/papers/6a7c4e34d501feb4353be92fhttps://doi.org/10.21608/ejvs.2015.801
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular and serological typing of foot-and-mouth disease virus serotypes currently circulating in Egypt2021 · 15 citations
  2. 2Molecular Epidemiology of FMDV in Northern Egypt (2012-214)2014 · 14 citations
  3. 3Sequence and phylogenetic analysis of FMD virus isolated from two outbreaks in Egypt2024 · 8 citations
  4. 4Rapid detection and isolation of Foot and Mouth Disease Virus in samples from clinically suspected animals in Egypt during 2016-2019.2020 · 9 citations
  5. 5Isolation and Molecular Characterization of Foot and Mouth Disease SAT2 Virus during Outbreak 2012 in Egypt2013 · 46 citations