Key result
Phylogenetic analysis of FMDV serotypes A, O, and SAT2 in Egypt between 2016 and 2019 revealed significant amino acid changes in critical antigenic sites between field isolates and vaccine strains.
Why the study?
Despite mass vaccination programs, foot and mouth disease virus persists in Egypt with repeated outbreaks of new lineages, making selection of appropriate vaccines difficult.
Observational
Continuous active surveillance and genetic analysis of FMDV are crucial for updating vaccine strains to control outbreaks in Egypt.
Answers are grounded in this paper and cite their sources.
Potential antigenic mismatches may reduce vaccine efficacy; leaves open whether updated strains will improve FMD control in Egypt.
Regardless mass vaccination programs in Egypt with inactivated polyvalent vaccines of FMDvirus. FMD virus is still persistent with major economic burden. Serotypes of FMD namely, A, O, and South African Territories (SAT2) are endemic with repeated outbreaks of new linage. So selection of appropriate vaccine is very difficult. In this study; Phylogenetic analysis of VP1 genome for the existing serotype (A, O, SAT2) between 2016 to 2019 approved circulation of serotype O of East Africa 3 (EA-3) topoype, AIran05 lineage and A Africa G-IV lineage of serotype A and topotype VII of serotype SAT2 including Alx-12 and Lib-12 lineages. Significant amino acid changes in critical antigenic sites between field isolates and vaccine strains were observed. The present findings indicate the importance of an active routine surveillance system incorporating antigenic and genetic analysis designated to continually update information about field isolates of FMDV. Such as this protocols might be affected on FMD strategy control in Egypt and surrounding country.
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Shahen et al. (2020) conducted an observational in Foot and mouth disease virus (FMDV). Phylogenetic analysis of field isolates versus vaccine strains was evaluated on Amino acid changes in critical antigenic sites. Phylogenetic analysis of FMDV serotypes A, O, and SAT2 in Egypt between 2016 and 2019 revealed significant amino acid changes in critical antigenic sites between field isolates and vaccine strains.
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