Key result
Analysis of 15 FMDV isolates from vaccinated animals in Egypt identified amino acid substitutions in antigenic sites that decreased neutralizing antibody titers, suggesting immune escape.
Population
Foot and mouth disease viruses circulating in Egyptian vaccinated animals
Design
Preclinical
Authors
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May indicate FMDV vaccine mismatch in Egypt; leaves open need for ongoing antigenic surveillance before strategy changes.
Observational (n=15)
Yes
Mutations in critical amino acids within the antigenic sites of FMDV isolates from vaccinated animals in Egypt contribute to decreased antibody neutralization and immune escape.
D et al. (2020) conducted an observational in Foot and mouth disease (n=15). FMDV infection despite vaccination was evaluated on Viral isolation, phylogenetic analysis, and virus neutralization test. Analysis of 15 FMDV isolates from vaccinated animals in Egypt identified amino acid substitutions in antigenic sites that decreased neutralizing antibody titers, suggesting immune escape.
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