Key result
Severe fetal vitamin K deficiency bleeding and intracranial hemorrhage can occur in utero due to hyperemesis gravidarum, despite normal maternal coagulation function.
Case Report (n=1)
Hyperemesis gravidarum can lead to severe fetal vitamin K deficiency and subsequent in utero intracranial hemorrhage, suggesting a need for close monitoring and potential vitamin K prophylaxis.
Alerts to rare fetal ICH risk in hyperemesis gravidarum; leaves open whether monitoring or prophylaxis alters outcomes.
In rare cases, severe fetal vitamin K deficiency bleeding may occur in utero as a result of insufficient vitamin K placental transfer. We present a case of a 32-week-preterm infant born with severe intracranial hemorrhage to a pregnant woman who suffered from hyperemesis gravidarum. Neonatal hematologic status was compatible with vitamin K deficiency whereas the maternal coagulation function was normal. This case emphasizes the potential risk of fetal bleeding owing to vitamin K deficiency in pregnancies complicated with hyperemesis gravidarum. These women should be closely monitored and vitamin K prophylaxis might be considered.
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Eventov‐Friedman et al. (2009) conducted a case report in Fetal intracranial hemorrhage and vitamin K deficiency associated with hyperemesis gravidarum (n=1). Hyperemesis gravidarum was evaluated on Fetal intracranial hemorrhage and vitamin K deficiency bleeding. Severe fetal vitamin K deficiency bleeding and intracranial hemorrhage can occur in utero due to hyperemesis gravidarum, despite normal maternal coagulation function.
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