Key result
Progressive menopausal stage and higher cardiorespiratory fitness were associated with lower flow-mediated dilation (P=0.005 and P=0.006, respectively), which inversely correlated with FSH.
Why the study?
To evaluate whether endothelial function differs before and after acute exercise in women across menopausal stages with high versus low cardiorespiratory fitness.
Does acute moderate intensity exercise affect flow-mediated dilation differently across menopausal stages and cardiorespiratory fitness levels?
Cross-Sectional (n=51)
Does acute moderate intensity exercise affect flow-mediated dilation differently across menopausal stages and cardiorespiratory fitness levels?
p-value: p=0.005
Endothelial function declines with progressive menopausal stages in high-fit women and is inversely associated with follicle-stimulating hormone levels.
Should not change practice; hypothesis-generating for menopausal stage, fitness, and FSH effects on endothelial function.
OBJECTIVE: The aim of the study was to evaluate if there are differences in endothelial function before and after acute exercise in women at different menopausal stages with high and low cardiorespiratory fitness. METHODS: Participants were healthy high-fit premenopausal (n = 11), perimenopausal (n = 12), and postmenopausal women (n = 13) and low-fit perimenopausal (n = 7) and postmenopausal women (n = 8). Brachial artery flow-mediated dilation (FMD) was measured before and after acute moderate intensity exercise. FMD was calculated as (Diameterpeak-Diameterbaseline)/ Diameterbaseline) × 100. Differences between high-fit women and between high- and low-fit perimenopausal and postmenopausal women were assessed with repeated-measure ANOVAs. Relations with FMD were assessed with Pearson correlations. RESULTS: FMD was reduced with progressive menopausal stage in high-fit women (P = 0.005) and was lower in perimenopausal compared to postmenopausal women (P = 0.047). FMD was lower in high-fit compared to low-fit women (P = 0.006) and there was no relation between FMD and VO2peak (P > 0.05). There was an inverse relation between FMD and follicle-stimulating hormone (P < 0.05), but not estradiol (P > 0.05). CONCLUSIONS: These data suggest that endothelial function is lower with progressive menopausal stage in women with high cardiorespiratory fitness; that FMD is lower in women with higher cardiorespiratory fitness; and that FSH, but not estradiol, is associated with FMD.
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Serviente et al. (2018) conducted a cross-sectional in Healthy women at different menopausal stages (n=51). Progressive menopausal stage and cardiorespiratory fitness vs. Earlier menopausal stages and low cardiorespiratory fitness was evaluated on Brachial artery flow-mediated dilation (FMD) (p=0.005). Progressive menopausal stage and higher cardiorespiratory fitness were associated with lower flow-mediated dilation (P=0.005 and P=0.006, respectively), which inversely correlated with FSH.
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