Key result
A rare case of slow-growing ALK-negative anaplastic large cell lymphoma localized to the mediastinum was successfully treated with thymectomy and chemoradiotherapy, with the patient remaining recurrence-free at 6 months.
Case Report (n=1)
No
This case report describes a rare presentation of ALK-negative anaplastic large cell lymphoma localized to the mediastinum that progressed slowly and asymptomatically over two years.
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May support multimodality therapy for rare mediastinal ALK-negative ALCL; hypothesis-generating and requires validation in larger cohorts.
症例は49歳女性．胸部CTにて左肺上葉のすりガラス陰影を指摘され，以後8年間定期的に経過観察中，2年前より緩徐に増大する前縦隔腫瘍を認めた．腫瘤は上行大動脈腹側に33×25×60mmで比較的均一な増強効果を示す腫瘤陰影として認め，MRIでは同部位にT1強調で中間信号，T2強調で低信号を呈し，Gd造影にて比較的よく染まる軟部腫瘤を認めた．表在リンパ節は触知せず，LDHおよび可溶性IL-2レセプターの上昇は認めなかった．画像上全身に他病変はなく，胸腺腫を疑い，胸骨正中切開にて腫瘤を含む胸腺摘除術を施行した．病理組織学的診断はanaplastic large cell lymphoma（ALCL；未分化大細胞型リンパ腫）であった．高悪性度群であるALK陰性ALCLであったが，病変は縦隔のみで，術前2年間無症状で緩徐に進行した稀な症例であり，放射線化学療法が施行され，現在まで術後6ヵ月無再発生存中である．
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敬祐 et al. (2010) conducted a case report in ALK-negative anaplastic large cell lymphoma (n=1). Thymectomy and chemoradiotherapy was evaluated on Clinical outcome. A rare case of slow-growing ALK-negative anaplastic large cell lymphoma localized to the mediastinum was successfully treated with thymectomy and chemoradiotherapy, with the patient remaining recurrence-free at 6 months.
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