Androgen Contributes to Gender-Related Cardiac Hypertrophy and Fibrosis in Mice Lacking the Gene Encoding Guanylyl Cyclase-A
Population
Male and female guanylyl cyclase-A knockout mice, wild-type mice, and double-KO mice for GC-A and AT1A
Comparison
Castration, flutamide, ovariectomy, or chronic… vs Untreated/control mice of the same genotypes, or…
Design
Preclinical
Follow-up
Evaluated at 16 weeks of age (interventions at 10 weeks)
Authors
Discussion
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Implication
Should not yet change clinical practice; hypothesis-generating for androgen effects on sex-specific cardiac remodeling.
Structured PICO
P
Population
Male and female guanylyl cyclase-A knockout (GC-A KO) mice, wild-type mice, and double-KO mice for GC-A and AT1A
I
Intervention
Castration (at 10 weeks of age), flutamide (androgen receptor antagonist), ovariectomy (at 10 weeks of age), or chronic testosterone infusion
C
Comparator
Untreated/control mice of the same genotypes, or opposite sex
O
Outcome
Cardiac hypertrophy and fibrosissurrogate
Androgens contribute to gender-related differences in cardiac hypertrophy and fibrosis through a mechanism involving AT1A receptors and GC-A in a mouse model.
Cite This Study
Li et al. (2003) studied this question.