June 1, 2004Annals of the New York Academy of Sciences
A Functional Subset of Serotonergic Neurons in the Rat Ventrolateral Periaqueductal Gray Implicated in the Inhibition of Sympathoexcitation and Panic
Population
Rats (focus on the ventrolateral periaqueductal gray)
Design
Review
Authors
Discussion
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Implication
Hypothesis-generating for serotonergic drugs in hypertension and panic; prospective trials needed before clinical adoption.
Structured PICO
P
Population
Rats (focus on the ventrolateral periaqueductal gray)
I
Intervention
Serotonin (5-HT) release and modulation
O
Outcome
Inhibition of sympathoexcitation and panic/fight-or-flight behaviors
A functional subpopulation of serotonergic neurons in the ventrolateral periaqueductal gray inhibits sympathoexcitation and panic, potentially explaining the efficacy of serotonergic drugs in treating hypertension and panic disorder.
Cite This Study
Johnson et al. (2004) studied this question.