April 1, 2001AJP Regulatory Integrative and Comparative Physiology

Sympathoinhibition from ventrolateral periaqueductal gray mediated by 5-HT1A receptors in the RVLM

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Population

Pentobarbital sodium-anesthetized rats (n=15)

Comparison

Microinjection of specific 5-HT1A-receptor… vs Pre-injection control levels

Design

Preclinical

Authors

MBM BagoMedical College of Wisconsin CDCaron DeanMedical College of Wisconsin

Discussion

Member takes

Implication

Implicates RVLM 5-HT1A receptors in vlPAG cardiovascular control in rats; leaves open translation to human autonomic therapies.

Structured PICO

Population

Pentobarbital sodium-anesthetized rats (n=15)

Intervention

Microinjection of specific 5-HT1A-receptor antagonist WAY-100635 into the pressor area of the rostral ventrolateral medulla (RVLM)

Comparator

Pre-injection control levels

Outcome

Changes in renal and lumbar sympathetic nerve activities and arterial blood pressure evoked by ventrolateral periaqueductal gray (vlPAG) activationsurrogate

Sympathoinhibition and hypotension elicited by activation of neurons in the vlPAG are mediated by 5-HT1A receptors in the RVLM in a rat model.

Cite This Study

Bago et al. (2001) studied this question.

synapsesocial.com/papers/6a83f2344b7d31ae448dd7fb https://doi.org/10.1152/ajpregu.2001.280.4.r976

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Sympathoinhibition from ventrolateral periaqueductal gray mediated by 5-HT1A receptors in the RVLM

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sympathoinhibition from ventrolateral periaqueductal gray mediated by 5-HT1A receptors in the RVLM

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider