Population
Saponin-skinned rat papillary muscle
Comparison
Solutions mimicking intracellular milieu changes… vs Control solutions
Design
Preclinical
Authors
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May distinguish Ca2+ handling in acute versus prolonged hypoxia; leaves open translation to human ischemia.
Intracellular milieu changes during short-term hypoxia depress contractility by inhibiting SR Ca2+ uptake, while changes during long-term hypoxia or ischemia can elevate intracellular Ca2+ by reversing the SR Ca2+ pump.
Zhu et al. (1991) studied this question.
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