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June 16, 2006BloodOpen Access

A prospective cohort study on the absolute incidence of venous thromboembolism and arterial cardiovascular disease in asymptomatic carriers of the prothrombin 20210A mutation

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Why the study?

Does carriership of the prothrombin 20210A mutation increase the risk of first VTE or arterial cardiovascular event in asymptomatic first-degree relatives?

Population

464 asymptomatic first-degree family members of patients with either VTE or premature atherosclerosis and…

Comparison

Carriers of the prothrombin 20210A mutation vs Noncarriers of the prothrombin 20210A mutation

Design

Cohort

Follow-up

Total 1816 patient-years (943 years for carriers)

Authors

MCMichiel CoppensVascular MedicineMPMarlène HW van de PoelLaurentius ZiekenhuisIBIvan BankSanquin

Discussion

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Implication

Low absolute risks with wide CIs in asymptomatic relatives; leaves open whether prothrombin 20210A testing alters management or warrants larger studies.

Structured PICO

Does carriership of the prothrombin 20210A mutation increase the risk of first VTE or arterial cardiovascular event in asymptomatic first-degree relatives?

P
Population
464 asymptomatic first-degree family members of patients with either VTE or premature atherosclerosis and the prothrombin 20210A mutation
I
Intervention
Carriers of the prothrombin 20210A mutation (n=236)
C
Comparator
Noncarriers of the prothrombin 20210A mutation
O
Outcome
Incidence of a first venous thromboembolism (VTE) or arterial cardiovascular eventhard clinical

The absolute incidence of VTE or arterial cardiovascular events is low in asymptomatic carriers of the prothrombin 20210A mutation, suggesting routine testing of first-degree relatives is not justified.

Cite This Study

Coppens et al. (2006) studied this question.

synapsesocial.com/papers/6a7c6d0566fdf7440826baaehttps://doi.org/10.1182/blood-2006-04-016527

Topics

Coronary artery disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis1996 · 3,130 citations
  2. 2A prospective study of the incidence of deep‐vein thrombosis within a defined urban population1992 · 786 citations
  3. 3Prothrombin 20210A Mutation2004 · 109 citations
  4. 4The 20210 A Allele of the Prothrombin Gene Is a Common Risk Factor among Swedish Outpatients with Verified Deep Venous Thrombosis1997 · 250 citations
  5. 5The incidence of venous thromboembolism in asymptomatic carriers of a deficiency of antithrombin, protein C, or protein S: a prospective cohort study.1999 · 178 citations