Why the study?
Does dichloroacetate or glycogen depletion alter infarct size or the infarct-limiting effect of ischaemic preconditioning in rabbit hearts?
Population
Anaesthetized open-chest rabbit model and isolated perfused rabbit heart model undergoing 45 min of regional…
Comparison
Dichloroacetate (300 + 150 mg kg IV) or glycogen… vs Saline vehicle or normal glycogen content
Design
Preclinical
Follow-up
3 hours of reperfusion
Authors
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Negative rabbit model results warrant no clinical extrapolation; leaves open metabolic modulation of ischemia-reperfusion injury in humans.
Does dichloroacetate or glycogen depletion alter infarct size or the infarct-limiting effect of ischaemic preconditioning in rabbit hearts?
Manipulations in glycogen metabolism via dichloroacetate or glycogen depletion do not influence infarct size or the protective effects of ischaemic preconditioning in rabbit hearts.
Gozal et al. (2002) studied this question.
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