July 1, 1994Cardiovascular Research

Superoxide dismutase and N-2-mercaptopropionyl glycine attenuate infarct size limitation effect of ischaemic preconditioning in the rabbit

View Full Paper

Ask AI

Bookmark

Why the study?

Does the administration of oxyradical scavengers (SOD, MPG, DMTU) attenuate the infarct size limiting effect of ischaemic preconditioning in a rabbit model of myocardial infarction?

Population

Anaesthetised open chest rabbits subjected to 30 min coronary occlusion and 48 h reperfusion (n=73)

Comparison

Oxyradical scavengers infused before and during… vs Placebo saline infused before and during…

Design

Preclinical

Follow-up

48 hours

Authors

MTMasaru TanakaKyushu University HFHisayoshi FujiwaraHeart Failure / Cardiomyopathy KYKyoko YamasakiCosmo Oil (Japan)

Discussion

Member takes

Implication

Supports radical mediation of preconditioning in rabbits; leaves open any clinical translation to human myocardial protection.

Structured PICO

Does the administration of oxyradical scavengers (SOD, MPG, DMTU) attenuate the infarct size limiting effect of ischaemic preconditioning in a rabbit model of myocardial infarction?

Population

Anaesthetised open chest rabbits subjected to 30 min coronary occlusion and 48 h reperfusion (n=73)

Intervention

Oxyradical scavengers (superoxide dismutase [SOD] 15,000 U.kg-1, N-2-mercaptopropionyl glycine [MPG] 20 mg.kg-1, or dimethylthiourea [DMTU] 500 mg.kg-1) infused before and during ischaemic preconditioning (5 min occlusion and 5 min reperfusion)

Comparator

Placebo saline infused before and during ischaemic preconditioning, and non-preconditioning control groups

Outcome

Microscopical infarct size (percent of area at risk) after 48 hours of reperfusionsurrogate

In a rabbit model, the cardioprotective effect of ischaemic preconditioning is attenuated by the oxyradical scavengers SOD and MPG, suggesting mediation by oxygen free radicals.

Cite This Study

Tanaka et al. (1994) studied this question.

synapsesocial.com/papers/6a7209f7439bab0cabc3be15 https://doi.org/10.1093/cvr/28.7.980

View Full Paper

Ask AI

Bookmark

Superoxide dismutase and N-2-mercaptopropionyl glycine attenuate infarct size limitation effect of ischaemic preconditioning in the rabbit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Superoxide dismutase and N-2-mercaptopropionyl glycine attenuate infarct size limitation effect of ischaemic preconditioning in the rabbit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider