Why the study?
Does inhibition of Na+,K+-ATPase with digoxin reduce the infarct size-limiting effect of preconditioning in rabbit hearts?
Population
Rabbit hearts subjected to coronary occlusion (0 to 60 minutes) and reperfusion
Comparison
Pretreatment with digoxin prior to 30 minutes of… vs Control rabbits and preconditioned rabbits…
Design
Preclinical
Follow-up
3 hours of reperfusion
Authors
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May blunt preconditioning cardioprotection in rabbits; hypothesis-generating for Na+,K+-ATPase role in human preconditioning.
Does inhibition of Na+,K+-ATPase with digoxin reduce the infarct size-limiting effect of preconditioning in rabbit hearts?
Preservation of sarcolemmal Na+,K+-ATPase activity during early ischemia is a key mechanism responsible for the cardioprotective, infarct size-limiting effect of ischemic preconditioning.
Nawada et al. (1997) studied this question.
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