Key result
Vericiguat, a direct soluble guanylate cyclase stimulator, is being evaluated as a therapeutic option for patients with chronic heart failure with reduced ejection fraction.
Why the study?
The nitric oxide-sGC-cGMP signalling pathway is disrupted in heart failure due to decreased NO bioavailability, leading to the study of vericiguat as a therapeutic option in chronic HFrEF.
Vericiguat, a direct sGC stimulator, is discussed as a therapeutic option targeting the cGMP signaling cascade in patients with chronic HFrEF.
No immediate change to HFrEF management; leaves open vericiguat's role pending randomized data.
Data from contemporary clinical trials have led to a multi-target approach aimed at the various pathophysiological mechanisms implicated in heart failure (HF). One of these pathways is the cyclic guanosine monophosphate (cGMP) signalling cascade, which forms the basis for the use of nitrates in heart failure with reduced ejection fraction (HFrEF). Under physiological conditions, nitric oxide (NO) is released by the vascular endothelium and catalyses soluble guanylate cyclase (sGC)-mediated cGMP production. An intracellular signalling cascade ensues, leading to decreased ventricular remodelling, myocardial thickening, fibrosis, and vascular constriction. This pathway becomes disrupted in HF as endothelial dysfunction and oxidative stress result in decreased NO bioavailability and cGMP production.1 As such, vericiguat, a direct sGC stimulator which also sensitizes sGC to NO, has been studied as a therapeutic option in patients with chronic HFrEF. The Soluble Guanylate Cyclase Stimulator in Heart Failure with Reduced Ejection Fraction Study (SOCRATES-REDUCED) was a Phase...
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Aziz et al. (2021) conducted a review in Heart failure with reduced ejection fraction (HFrEF). Vericiguat was evaluated. Vericiguat, a direct soluble guanylate cyclase stimulator, is being evaluated as a therapeutic option for patients with chronic heart failure with reduced ejection fraction.