Key result
Early hospital mortality was primarily predicted by the need for inotropic and vasopressor drugs, while late hospital mortality was strongly predicted by pulmonary edema, pneumonia, and acute kidney injury.
Why the study?
The study was conducted to analyze the leading causes of early (first two days) and late (after the second day) hospital mortality among patients with acute decompensated heart failure.
Cohort (n=718)
No
Severe congestion, low blood pressure requiring inotropes or vasopressors, and renal dysfunction are key predictors of early hospital mortality in ADHF, while pneumonia strongly predicts late mortality.
Objective: to analyze the leading causes of early (first two days) and late (after the second day) hospital mortality among of patients with acute decompensated heart failure. Materials and methods: a retrospective single-center cohort (n=718) of patients with acute decompensated heart failure. Results: predictors of prognosis for early hospital mortality were pulmonary edema, hepatomegaly, the need for inotropic and vasopressive drugs, the level of systolic blood pressure and creatinine. Predictors of prognosis for late hospital mortality were pulmonary edema, the need for inotropic drugs, community-acquired pneumonia, and laboratory markers of acute renal injury. Conclusion: Tactical approaches are proposed to reduce hospital mortality of patients with acute decompensated heart failure.
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Polyakov et al. (2021) conducted a cohort in Acute decompensated heart failure (n=718). Clinical and laboratory risk factors (e.g., pulmonary edema, pneumonia, inotropic/vasopressor use, acute kidney injury) vs. Absence of these risk factors was evaluated on Early (first 2 days) and late (after 2 days) hospital mortality. Early hospital mortality was primarily predicted by the need for inotropic and vasopressor drugs, while late hospital mortality was strongly predicted by pulmonary edema, pneumonia, and acute kidney injury.
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