Key result
Higher remnant cholesterol levels were strongly associated with increased odds of arterial stiffness (OR 1.59) compared to traditional lipid parameters, remaining significant even when other lipids were controlled.
Why the study?
Studies evaluating the relationship between remnant cholesterol and arterial stiffness are limited.
Cross-Sectional (n=4,653)
Yes
Odds Ratio: 1.59 (95% CI 1.3–1.95)
p-value: p=<0.001
Remnant cholesterol is more strongly associated with arterial stiffness than traditional lipids and lipid ratios, suggesting it may be a valuable marker for early vascular risk assessment.
Remnant cholesterol may better flag arterial stiffness risk than standard lipids; leaves open causal role and need for prospective trials.
AIM: Studies on the relationship between remnant cholesterol (RC) and arterial stiffness (AS) are limited. This study aims to investigate the relationship between RC and AS and to explore RC, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), non-HDL-C, LDL-C/HDL-C, TG/HDL-C, lipoprotein combine index (LCI), and TC/HDL-C, which are lipid parameters most strongly associated with AS. METHODS: A total of 4653 participants from the REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals) study were recruited. AS was defined as a brachial-ankle pulse wave velocity of ≥ 1400 cm/s. Multiple logistic regression analyses were performed to detect its association with lipid parameters (RC, TG, TC, HDL-C, LDL-C, non-HDL-C, LDL-C/HDL-C, TG/HDL-C, LCI, and TC/HDL-C). RESULTS: Logistic regression analysis showed that compared with other traditional or non-traditional lipid parameters, the association between RC and AS was the strongest (odds ratio (OR) 1.59, 95% confidence interval (CI) 1.30-1.95, P＜0.001). In the stratified analysis, RC was significantly associated with AS in both sexes and at any age, as well as blood glucose, blood pressure, and body mass index levels. Besides, RC and AS were still significantly associated when TG＜1.7 mmol/L (OR:1.58, 95% CI: 1.02-2.45, P=0.04), LDL-C ＜3.4 mmol/L (OR:1.32, 95% CI: 1.01-1.73, P=0.041), HDL-C ≥ 1.0 mmol/L (OR:1.67, 95% CI: 1.34-2.08, P＜0.001), or non-HDL-C＜4.1 mmol/L (OR: 1.42, 95% CI: 1.10-1.82, P=0.007) are controlled within the appropriate range. CONCLUSION: In conclusion, compared with traditional lipids and lipid ratios, RC is more strongly associated with AS. The association between RC and AS remains significant even when TG, LDL-C, HDL-C, or non-HDL-C levels are controlled within the appropriate range.
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Li et al. (2023) conducted a cross-sectional in Arterial stiffness (n=4,653). Remnant cholesterol vs. Lowest quartile of remnant cholesterol was evaluated on Arterial stiffness (brachial-ankle pulse wave velocity ≥ 1400 cm/s) (OR 1.59, 95% CI 1.30-1.95, p=<0.001). Higher remnant cholesterol levels were strongly associated with increased odds of arterial stiffness (OR 1.59) compared to traditional lipid parameters, remaining significant even when other lipids were controlled.
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