cBIN1 Score (CS) Identifies Ambulatory HFrEF Patients and Predicts Cardiovascular Events

Figures

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  FIGURE 1. Distribution of CS among HFrEF and matched controls. The vertical axis is the cBIN1 score (CS), and the width of each violin graph depicts the density plot at each measured value. The HFrEF cohort median CS is elevated relative to the controls, 1.9 (IQR 1.4–2.4) compared to 0 (IQR -0.5–0.7), respectively (p < 0.0001).

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  FIGURE 2. Receiver operating characteristic (ROC) curves. ROC curve containing the various sensitivities and specificities of CS (AUC = 0.973, red), NT-proBNP (AUC = 0.967, blue), and combined NT-proBNP and CS (AUC = 0.995, green) to diagnose disease in our control and HFrEF cohorts.

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  FIGURE 3. Cardiovascular event free survival of HFrEF patients during 12-month follow-up. (A) Kaplain-Meier survival curve is shown here for all HFrEF patients. The red line demonstrates patients with CS < 1.9 and the blue line demonstrate patients with CS ≥ 1.9. Event free survival is defined as patients who did not have a cardiovascular (CV) event (HF-related hospitalization, cardiac hospitalization, LVAD, OHT, or death) during 12-months follow-up. A low CS (<1.9) predicted a higher event-free survival among all HFrEF patients (p = 0.01). (B) Scatterplot of 12-month event-free survival vs. CS for all CS ≥ 1.9 indicates a negative correlation (Pearsons’s correlation coefficient −0.91, p < 0.0001).