Key result
Higher cystatin C, chromogranin A, and SFRP-5 linked to worsening cardiac function and remodeling in HF.
Why the study?
The study was conducted to explore the relationship between peripheral blood expression of CysC, TIMP-1, and SFRP-5 and cardiac remodeling and prognosis in chronic heart failure.
Do peripheral blood levels of CysC, TIMP-1, and SFRP-5 correlate with cardiac remodeling, disease severity, and quality of life in patients with chronic heart failure?
Observational (n=240)
Do peripheral blood levels of CysC, TIMP-1, and SFRP-5 correlate with cardiac remodeling, disease severity, and quality of life in patients with chronic heart failure?
Peripheral blood levels of CysC, CgA, and SFRP-5 are elevated in chronic heart failure and significantly correlate with disease severity, ventricular remodeling, and reduced quality of life.
May refine severity assessment in chronic heart failure; extends observational biomarker data but leaves practice change open.
To explore the relationship between the expression of cystatin C (CysC), tissue inhibitor of metalloproteinases-1 (TIMP-1), and secret fuzzed-related protein 5 (SFRP-5) in peripheral blood and cardiac remodeling and prognosis in chronic heart failure (CHF). It recruited 180 CHF patients and 60 healthy volunteers for comparison. Patients were divided into grade IV, III, and II groups based on cardiac function grading. Blood levels of N-terminal pro B-type natriuretic peptide (NT proBNP), CysC, chromogranin A (CgA), and echocardiography were analyzed. Treatment effects on cardiac function and quality of life were assessed using Minnesota Living with Heart Failure Questionnaire scale. Correlation between CysC, TIMP-1, SFRP-5 levels, and cardiac function was analyzed. No significant difference in general information among patients in each group. Patients with CHF had higher levels of CysC, CgA, and SFRP-5 compared to controls. NT proBNP, CysC, CgA, and SFRP-5 levels increased with worsening cardiac function. Left ventricular parameters worsened with increasing cardiac function level. Minnesota Living with Heart Failure Questionnaire score and levels of CgA, CysC, and SFRP-5 were positively correlated. CgA, CysC, and SFRP-5 levels were negatively correlated with left ventricular ejection fraction but positively correlated with NT proBNP and left ventricular mass index. Serum CgA and CysC levels in patients with CHF are correlated with cardiac function grade and ventricular remodeling, and SFRP-5 is one of the potential biomarkers of CHF.
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Di et al. (2026) conducted an observational in Chronic heart failure (n=240). Peripheral blood levels of CysC, CgA, and SFRP-5 vs. Healthy volunteers was evaluated on Cardiac function and ventricular remodeling. Elevated peripheral blood levels of CysC, CgA, and SFRP-5 in patients with chronic heart failure were correlated with worsening cardiac function and left ventricular remodeling.
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