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The basis of the established subdivision of receptors for purines into P1-purinoceptors for adenosine and P2-purinoceptors for ATP and ADP is considered, as well as the proposals for subdivision of P1-purinoceptors into A1 and A2 subtypes and of ATP receptors into P2x-, P2y- P2z- and P2T-purinoceptor subtypes. The distribution and roles of these receptor subtypes in muscles, nerves and other tissues, including endothelial and epithelial cells, hepatocytes, blood cells, fibroblasts and astrocytes, are discussed.
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Geoffrey Burnstock (1991) studied this question.
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