Thioredoxin-1 and Correlations of the Plasma Cytokines Regarding Aortic Valve Stenosis Severity

Figures

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  Figure 1. Plasma CRP level: (a) comparison of CRP concentration in control subjects and aortic valve stenosis (AS) patients; (b) comparison of CRP concentration in control subjects and AS patients with 3 different severity degrees; (c) correlation of CRP regarding AS severity degrees. rP—Pearson’s correlation coefficient; MW—Mann–Whitney test, KW—Kruskal–Wallis test with a post hoc procedure.

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  Figure 2. Plasma thioredoxin-1 (TRX1): (a) comparison of TRX1 concentration in control subjects and aortic valve stenosis (AS) patients. Wtt—Welch t test; (b) estimation plot displaying the raw data and the 95% confidence interval for the difference between means; (c) receiver-operating characteristic curve for TRX1 as a diagnostic marker of AS (control group vs. AS patient group). AUC—the area under the curve.

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  Figure 3. Correlation and regression line of thioredoxin-1 (TRX1) regarding AS severity degrees. rP—Pearson’s correlation coefficient.

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  Figure 4. Comparison of plasma thioredoxin-1 (TRX1) concentration in mild, moderate and severe aortic valve stenosis (AS) patients to control subjects. KW—Kruskal–Wallis test; z-score—distance of data point from the control mean, expressed in standard deviations.

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  Figure 5. Receiver-operating characteristic curve for thioredoxin-1 (TRX1) as a diagnostic marker of AS (control group vs. mild AS patient group). AUC—the area under the curve.

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  Figure 6. Correlative associations of the studied biomarkers: (a) regarding control and AS patients; (b) regarding TRX1 and biomarkers in control and AS patients; (c) comparative changes in correlative relation and respective biomarkers; rP and rS: correlation coefficients (Pearson’s and Spearman’s, respective); green arrows show the most pronounced difference between correlation coefficients of the respective biomarker, that was calculated by expression Δr = rmax − rmin; closeness of associative relations is characterized by p-value—* 0.08 < p > 0.05, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

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  Figure 7. Corelation of studied biomarkers regarding severity of AS (0—no (control), 1—mild, 2—moderate, 3—severe; closeness of associative relations is characterized by p-value—* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001; green frame); covariances of studied biomarkers (orange frame); rP—Pearson’s correlation coefficients, rS—Spearman’s rank correlation coefficients.

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  Figure 8. Correlation between MPO and MMP-9 levels in the aortic valve stenosis patients.