Why the study?
Does regular exercise training improve endothelial function in humans with cardiovascular disease?
Does regular exercise training improve endothelial function in humans with cardiovascular disease?
Regular exercise training is an effective nonpharmacological intervention to improve endothelial dysfunction, an independent predictor of cardiovascular events, by increasing nitric oxide bioavailability.
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Supports exercise as adjunct therapy in CVD; extends mechanistic evidence but leaves open effects on clinical outcomes.
In Brief WALTHER, C., S. GIELEN, and R. HAMBRECHT. The effect of exercise training on endothelial function in cardiovascular disease in humans. Exerc. Sport Sci. Rev., Vol. 32, No. 4, pp. 129–134, 2004. Endothelial dysfunction occurs early in atherosclerosis in response to cardiovascular risk factors. The occurrence of endothelial dysfunction is primarily the result of reduced nitric oxide (NO) bioavailabilty. It represents an independent predictor of cardiovascular events and predicts the prognosis of the patient. Therefore, endothelial function has been identified as a target for therapeutic intervention. Regular exercise training is a nonpharmacological option to improve endothelial dysfunction in patients with cardiovascular disease by increasing NO bioavailability. Endothelial dysfunction is an independent predictor of cardiovascular events and can be improved by exercise via increasing nitric oxide bioavailability.
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Walther et al. (2004) studied this question.
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