An 8-week exercise training program in 75 subjects significantly improved vascular function, but these improvements were not correlated with changes in traditional cardiovascular risk factors.
RCT (n=75)
Cross-over
Does 8-week exercise training improve endothelial dysfunction independently of changes in cardiovascular risk factors in patients with diverse vascular function?
Short-term exercise training improves vascular function in patients with antecedent vascular dysfunction independently of changes in traditional cardiovascular risk factors.
We have pooled data from a series of our exercise training studies undertaken in groups with a broad range of vascular (dys) function to the examine the hypothesis that exercise-induced improvements in the conduit and/or resistance vessel function are related to improvements in risk factors for cardiovascular (CV) disease. Endothelium-dependent and -independent conduit vessel function were assessed by using wall tracking of high-resolution ultrasound images of the brachial artery response to flow-mediated dilation (FMD) and glyceryl trinitrate. Resistance vessel function was assessed using intrabrachial administration of acetylcholine (ACh), sodium nitroprusside, and NG-monomethyl-l-arginine. Randomized cross-over studies of 8-wk exercise training were undertaken in untreated hypercholesterolemic (n = 11), treated hypercholesterolemic (n = 11), coronary artery disease (n = 10), chronic heart failure (n = 12), Type 2 diabetic (n = 15), and healthy control subjects (n = 16). Exercise training did not significantly alter plasma lipids, blood pressure, blood glucose, waist-to-hip ratio, or body mass index values, despite significant improvement in both FMD and ACh responses. There were no correlations between changes in any risk factor variables and indexes of either resistance or conduit vessel function. We conclude that, in these subjects with antecedent vascular dysfunction, the beneficial effects of relatively short-term exercise training on vascular function are not solely mediated by the effects of exercise on CV risk factors.
Green et al. (Mon,) conducted a rct in Vascular dysfunction and cardiovascular risk factors (n=75). Exercise training vs. Control period (cross-over) was evaluated on Correlation between changes in cardiovascular risk factors and indexes of resistance or conduit vessel function. An 8-week exercise training program in 75 subjects significantly improved vascular function, but these improvements were not correlated with changes in traditional cardiovascular risk factors.