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February 1, 1986Poultry ScienceOpen Access

Genetic Aspects of Antibody Responses in Chickens to Different Classes of Antigens ,

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Authors

NGN.R. GylesAgricultural Research ServiceHFH. FALLAH-MOGHADDAMUniversity of Arkansas at FayettevilleLPL. T. PattersonUniversity of Arkansas at Fayetteville

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Implication

Comparative challenge study demonstrates B blood group haplotypes dictate antibody responses and tumor regression in chickens, indicating genetic regulation of immune competence.

Key Points

  • To evaluate how different B blood group haplotypes influence antibody production against multiple classes of antigens and affect tumor regression after Rous sarcoma virus exposure in chickens.
  • Evaluated six chicken breeding groups characterized by distinct B blood group system haplotypes.
  • Challenged parent chickens at 20 weeks of age and offspring at 3 weeks of age with five antigens (Newcastle disease vaccine, infectious bronchitis vaccine, infectious bursal disease viral agent, Salmonella pullorum antigen, and sheep red blood cells), determining antibody titers up to 4 weeks post-challenge.
  • Inoculated 8-week-old offspring in the wing-web with Rous sarcoma virus (RSV) and recorded individual tumor scores weekly over a 10-week period.
  • Breeding groups exhibited statistically significant differences in antibody titers among parents for ND, IB, P, and SRBC (P < .01) and among offspring across all five antigens (P < .05).
  • Accumulative 10-week tumor scores differed significantly across breeding groups (P < .01), with tumor-regressing lines (R-lines) demonstrating superior tumor resistance over progressive lines (Pr-lines) (P < .01).
  • R-lines produced significantly higher antibody titer responses than Pr-lines exclusively when challenged with sheep red blood cells (P < .01).

Cite This Study

Gyles et al. (1986) studied this question.

synapsesocial.com/papers/6a7c7d60169fe1af7cc2c523https://doi.org/10.3382/ps.0650223
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic Analysis of Primary and Secondary Immune Responses in the Chicken1983 · 77 citations
  2. 2Divergent Selection of Chickens for Antibody Response to Sheep Erythrocytes: Kinetics of Primary and Secondary Immunizations1985 · 30 citations
  3. 3Relationship of Blood Type to Histocompatibility in Chickens1961 · 268 citations
  4. 4Complementation of Major Histocompatibility Haplotypes in Regression of Rous Sarcoma Virus-Induced Tumors in Noninbred Chickens ,1982 · 22 citations