What question did this study set out to answer?

To assess genetic variation and relationships among humoral, innate, and cell-mediated immune responses across defined sublines of White Leghorn chickens.

July 1, 1988Poultry ScienceOpen Access

Genetic Analysis of Immunocompetence Measures in a White Leghorn Chicken Line

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Authors

SLSusan J. LamontIowa State University

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Implication

Genetic analysis reveals subline and sex variations in immune response in chickens, suggesting breeding requires evaluating full immunocompetence profiles.

Key Points

To assess genetic variation and relationships among humoral, innate, and cell-mediated immune responses across defined sublines of White Leghorn chickens.
Evaluated eight sublines of Iowa State University S1 White Leghorns categorized by erythrocyte antigen B alleles (B1B1 or B19B19), GAT antibody response, and Rous sarcoma virus tumor response.
Measured vaccine antibody responses against Pasteurella multocida, Mycoplasma gallisepticum, and infectious bursal disease virus using ELISA, phagocytic activity using carbon clearance, and T cell-mediated response via phytohemagglutinin injection.
Significant haplotype (subline) and sire family differences occurred across antibody responses, phagocytic activity, and T cell-mediated responses.
Haplotypes with high antibody responses to GAT exhibited significantly higher antibody titers to P. multocida and M. gallisepticum vaccines, alongside significant positive correlations between antibody levels to both vaccines.
Sex significantly influenced phagocytic activity and T cell-mediated responses, including a significant negative correlation between phagocytic activity and T cell response in females.

Cite This Study

Susan J. Lamont (1988) studied this question.

synapsesocial.com/papers/6a82a9650f52607ca18ae064 https://doi.org/10.3382/ps.0670989

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July 1, 1988Poultry ScienceOpen Access

Genetic Analysis of Immunocompetence Measures in a White Leghorn Chicken Line

View Full Paper

Ask AI

Bookmark

Authors

SLSusan J. LamontIowa State University

Discussion

Member takes

Implication

Genetic analysis reveals subline and sex variations in immune response in chickens, suggesting breeding requires evaluating full immunocompetence profiles.

Key Points

To assess genetic variation and relationships among humoral, innate, and cell-mediated immune responses across defined sublines of White Leghorn chickens.
Evaluated eight sublines of Iowa State University S1 White Leghorns categorized by erythrocyte antigen B alleles (B1B1 or B19B19), GAT antibody response, and Rous sarcoma virus tumor response.
Measured vaccine antibody responses against Pasteurella multocida, Mycoplasma gallisepticum, and infectious bursal disease virus using ELISA, phagocytic activity using carbon clearance, and T cell-mediated response via phytohemagglutinin injection.
Significant haplotype (subline) and sire family differences occurred across antibody responses, phagocytic activity, and T cell-mediated responses.
Haplotypes with high antibody responses to GAT exhibited significantly higher antibody titers to P. multocida and M. gallisepticum vaccines, alongside significant positive correlations between antibody levels to both vaccines.
Sex significantly influenced phagocytic activity and T cell-mediated responses, including a significant negative correlation between phagocytic activity and T cell response in females.

Cite This Study

Susan J. Lamont (1988) studied this question.

synapsesocial.com/papers/6a82a9650f52607ca18ae064 https://doi.org/10.3382/ps.0670989

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