Key result
GLP-1 did not significantly affect overall myocardial glucose uptake during normoglycemia or hypoglycemia, but increased uptake in subjects with low baseline uptake and decreased it in those with high baseline uptake.
Why the study?
Does acute GLP-1 infusion alter myocardial glucose uptake in healthy men during normoglycemia or hypoglycemia?
Population
18 healthy, non-smoking, Caucasian men with no history of diabetes or cardiovascular disease.
Comparison
Intravenous synthetic GLP-1 at a rate of 1.2… vs Matching placebo infused during the same clamp…
Design
RCT, Randomized, crossover studies. Each subject was studied twice in random…
Follow-up
Acute (during 360-400 minute clamp session)
Authors
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Acute GLP-1 leaves overall myocardial glucose uptake unchanged in healthy men; extends evidence for baseline-dependent modulation during glycemic stress.
RCT (n=18)
double-blinded
randomized
No
Does acute GLP-1 infusion alter myocardial glucose uptake in healthy men during normoglycemia or hypoglycemia?
Absolute Event Rate: 0.14% vs 0.17%
p-value: p=0.21
Acute GLP-1 infusion does not alter overall myocardial glucose uptake in healthy men, but it modulates uptake based on baseline levels and preserves it during hypoglycemia in insulin-resistant subjects.
Gejl et al. (2014) conducted an RCT in Healthy subjects (n=18). GLP-1 vs. Placebo was evaluated on Myocardial glucose uptake (MGU) during normoglycemia (p=0.21). GLP-1 did not significantly affect overall myocardial glucose uptake during normoglycemia or hypoglycemia, but increased uptake in subjects with low baseline uptake and decreased it in those with high baseline uptake.
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