What question did this study set out to answer?

To evaluate arterial wall responses and metabolic remodeling under plaque-prone hemodynamics, specifically oscillatory shear stress mimicking arterial branch points.

January 1, 2005Journal of Vascular ResearchOpen Access

Arterial Wall Response to ex vivo Exposure to Oscillatory Shear Stress

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Population

Porcine carotid arteries

Comparison

Ex vivo exposure to oscillatory shear stress… vs Ex vivo exposure to unidirectional high and low…

Design

Preclinical

Follow-up

3 days

Authors

VGVeronica GambillaraÉcole Polytechnique Fédérale de Lausanne GMGabriela MontorziHaemophilia Foundation Australia CHChristelle Haziza‐PigeonInserm

Discussion

Member takes

Implication

Supports oscillatory shear in vascular remodeling; hypothesis-generating for atherogenesis mechanisms, requires human validation.

Key Points

To evaluate arterial wall responses and metabolic remodeling under plaque-prone hemodynamics, specifically oscillatory shear stress mimicking arterial branch points.
Mounted porcine carotid artery segments in an ex vivo perfusion system for 3 days.
Exposed vessels to unidirectional high shear stress (6 ± 3 dyn/cm²), unidirectional low shear stress (0.3 ± 0.1 dyn/cm²), or oscillatory shear stress (0.3 ± 3 dyn/cm²).
Assessed matrix turnover alongside smooth muscle cell differentiation, migration, and contractile capacity.
Arteries exposed to oscillatory shear stress showed increased expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 compared to unidirectional flow.
Plasminogen activator inhibitor-1 expression significantly decreased under oscillatory shear stress relative to unidirectional conditions.
Smooth muscle cells maintained full contractile capacity and showed no phenotypic alterations across any perfusion condition after 3 days.

Structured PICO

Population

Porcine carotid arteries

Intervention

Ex vivo exposure to oscillatory shear stress (0.3 +/- 3 dyn/cm(2)) for 3 days

Comparator

Ex vivo exposure to unidirectional high and low shear stress (6 +/- 3 and 0.3 +/- 0.1 dyn/cm(2)) for 3 days

Outcome

Arterial metabolism assessed in terms of matrix turnover, smooth muscle cell function, differentiation, and migrationsurrogate

Plaque-prone hemodynamic environments characterized by oscillatory shear stress trigger vascular wall remodeling and metabolic changes implicated in atherogenesis.

Cite This Study

Gambillara et al. (2005) studied this question.

synapsesocial.com/papers/6a7c88252fb2fd2a5c4dcd30 https://doi.org/10.1159/000088343

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Arterial Wall Response to ex vivo Exposure to Oscillatory Shear Stress

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Arterial Wall Response to ex vivo Exposure to Oscillatory Shear Stress

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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