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June 6, 2006CirculationOpen Access

Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress

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Why the study?

Does lowered shear stress induce larger and more vulnerable atherosclerotic plaques compared to oscillatory shear stress in mouse carotid arteries?

Population

Mouse carotid arteries (in vivo model of atherosclerosis)

Comparison

Perivascular shear stress modifier inducing… vs Regions of oscillatory shear stress or increased…

Design

Preclinical

Authors

CCCaroline ChengVascular / Pulmonary VascularDTDennie TempelGoethe University FrankfurtRHRien van HaperenErasmus MC

Discussion

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Implication

Hypothesis-generating in mice; leaves open whether lowered shear stress promotes vulnerable human plaques.

Key Points

  • This research aims to understand how different shear stress patterns affect atherosclerotic lesion size and vulnerability.
  • Developed a perivascular shear stress modifier in mouse carotid arteries.
  • Induced varied shear stress conditions: lowered, increased, and lowered/oscillatory.
  • Examined plaque formation, composition, and inflammatory response.
  • Lowered shear stress regions showed larger lesions (1.38 ± 0.68 vs. 0.22 ± 0.04, p<0.001).
  • Lowered shear stress lesions had fewer smooth muscle cells (1.9 ± 1.6% vs. 26.3 ± 9.7%, p<0.001) and more lipids (15.8 ± 0.9% vs. 10.2 ± 0.5%, p<0.001).
  • Increased inflammatory mediator expression and metalloproteinase activity were found in lowered shear stress areas.

Structured PICO

Does lowered shear stress induce larger and more vulnerable atherosclerotic plaques compared to oscillatory shear stress in mouse carotid arteries?

P
Population
Mouse carotid arteries (in vivo model of atherosclerosis)
I
Intervention
Perivascular shear stress modifier inducing regions of lowered shear stress
C
Comparator
Regions of oscillatory shear stress or increased shear stress
O
Outcome
Plaque formation, size (intima/media ratio), and composition (smooth muscle cells, collagen, lipids)surrogate

In a mouse model, lowered shear stress induces larger atherosclerotic lesions with a vulnerable plaque phenotype, whereas oscillatory shear stress induces stable lesions.

Cite This Study

Cheng et al. (2006) studied this question.

synapsesocial.com/papers/69fc246d24cc0af589fa3aa0https://doi.org/10.1161/circulationaha.105.590018
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oscillatory Shear Stress Stimulates Adhesion Molecule Expression in Cultured Human Endothelium1998 · 550 citations
  2. 2Accelerated Atherosclerosis by Placement of a Perivascular Cuff and a Cholesterol-Rich Diet in ApoE*3Leiden Transgenic Mice2000 · 76 citations
  3. 3Effect of Endothelial Shear Stress on the Progression of Coronary Artery Disease, Vascular Remodeling, and In-Stent Restenosis in Humans2003 · 434 citations
  4. 4Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype1999 · 390 citations
  5. 5Presence of Intraplaque Hemorrhage Stimulates Progression of Carotid Atherosclerotic Plaques2005 · 560 citations