Why the study?
Does Clariscan-enhanced MR imaging accurately characterize the spatial extent of microvascular injury in ischemically injured rat myocardium compared to histochemical staining?
Population
20 rats undergoing 45 minutes of coronary artery occlusion and 3 hours of reperfusion
Comparison
Clariscan enhanced MR imaging vs Histochemical staining at necropsy and…
Design
Preclinical
Follow-up
3 hours of reperfusion
Authors
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Clariscan-enhanced MRI may estimate microvascular injury extent in rat reperfusion; leaves open validation and clinical translation in humans.
Does Clariscan-enhanced MR imaging accurately characterize the spatial extent of microvascular injury in ischemically injured rat myocardium compared to histochemical staining?
Clariscan-enhanced MR imaging can estimate the spatial extent of microvascular injury in reperfused myocardium, potentially serving as a marker after thrombolytic therapy.
Krombach et al. (2002) studied this question.
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