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April 1, 1990Circulation ResearchOpen Access

Functional coronary microvascular injury evident as increased permeability due to brief ischemia and reperfusion.

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Why the study?

Does brief ischemia and reperfusion cause functional coronary microvascular injury in anesthetized dogs?

Population

Anesthetized dogs

Comparison

Left anterior descending coronary artery… vs 0 minutes of occlusion (control)

Design

Preclinical

Follow-up

60 minutes of reperfusion

Authors

IDI M DauberUniversity of Colorado HospitalKVKaryl M. VanBenthuysenUnited States Department of Veterans AffairsIMIvan F. McMurtryAmerican Heart Association

Discussion

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Implication

Brief ischemia induces functional microvascular permeability changes in canine models; extends experimental observations but leaves open relevance to human coronary disease.

Structured PICO

Does brief ischemia and reperfusion cause functional coronary microvascular injury in anesthetized dogs?

P
Population
Anesthetized dogs
I
Intervention
Left anterior descending coronary artery occlusion for 15, 30, or 60 minutes followed by 60 minutes of reperfusion
C
Comparator
0 minutes of occlusion (control)
O
Outcome
Microvascular permeability quantitatively assessed as a protein leak index (rate of extravascular accumulation of radiolabeled protein normalized for vascular surface area)surrogate

Even brief ischemia and reperfusion cause functional coronary vascular injury, evident as increased microvascular permeability and impaired endothelium-dependent vasodilation, before morphological changes occur.

Cite This Study

Dauber et al. (1990) studied this question.

synapsesocial.com/papers/6a792bd52eb3c7e469f36796https://doi.org/10.1161/01.res.66.4.986
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coronary Vascular Reactivity After Acute Myocardial Ischemia1982 · 329 citations
  2. 2Specificity and sensitivity of noninvasive measurement of pulmonary vascular protein leak1985 · 78 citations
  3. 3Antiarrhythmic agents diminish thiourea-induced pulmonary vascular protein leak in rats1987 · 35 citations
  4. 4Microvascular deterioration: implications for reperfusion1984 · 24 citations