Population
Isolated, perfused rabbit hearts
Comparison
30 and 60 minutes of global, no-flow ischemia… vs 3-hour control perfusions
Design
Preclinical
Follow-up
Up to 3 hours
Authors
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Microvascular dysfunction may persist after reperfusion despite LV recovery; hypothesis-generating for human ischemia-reperfusion studies.
Microvascular dysfunction and compromised vascular integrity occur early after ischemia and persist even when left ventricular mechanical function recovers.
Tilton et al. (1983) studied this question.
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