What question did this study set out to answer?

To determine whether birth weight is associated with adult body composition—specifically bone, lean, and fat mass—in older adults.

January 1, 2001The Journal of Clinical Endocrinology & Metabolism

Intrauterine Programming of Adult Body Composition

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To determine whether birth weight is associated with adult body composition—specifically bone, lean, and fat mass—in older adults.
Assessed a cohort of 143 men and women aged 70–75 years born and residing in Sheffield, UK.
Obtained neonatal anthropometric records (birth weight, length, head size, and abdominal circumference) and measured adult body composition via dual-energy x-ray absorptiometry.
Adjusted statistical models for age, sex, adult height, smoking, alcohol use, dietary calcium intake, and physical inactivity.
Birth weight showed significant positive associations with adult whole-body bone mass and lean mass in both sexes (P < 0.01).
Significant associations were observed between birth weight and bone mineral content at the lumbar spine and femoral neck (P < 0.03).
Whole-body bone mineral and lean mass relationships remained significant after multivariable adjustment, whereas associations with whole-body fat mass were weak and non-significant.

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Implication

Cohort study reveals positive associations between birth weight and adult bone and lean mass in older adults, suggesting intrauterine influences program long-term musculoskeletal health.

Cite This Study

Catharine R. Galé (2001) studied this question.

synapsesocial.com/papers/6a7c9097fecf32cfa0610e50 https://doi.org/10.1210/jc.86.1.267

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Implication

Cohort study reveals positive associations between birth weight and adult bone and lean mass in older adults, suggesting intrauterine influences program long-term musculoskeletal health.

Intrauterine Programming of Adult Body Composition

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Discussion

Implication

Cite This Study

Intrauterine Programming of Adult Body Composition

Key Points

Discussion

Implication

Cite This Study

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