Sympathetic Skin Response and Galvanic Skin Resistance in Males With Type 2 Diabetes Mellitus

BACKGROUND mellitus, a metabolic disorder affects the nervous system due to alteration in various metabolic pathways. As manifests in longstanding diabetes mellitus, autonomic nervous system also gets affected. The study was started on the hypothesis that the sweat glands innervated by autonomic nervous system will be affected in patients with type 2 diabetes mellitus patients with clinical features of neuropathy. This study was undertaken to compare the sympathetic skin (SSR) and galvanic skin resistance (GSR) in males with type 2 diabetes mellitus and in controls. males in the age group of 45-55 years, known to have diabetes mellitus and having a history of neuropathic symptoms as subjects and thirty males in the same age group with no history of diabetes mellitus and neuropathy served as . SSR and GSR were recorded using Recorders and Medicare Systems 4 channel polygraph in the noise and light research laboratory, Department of Physiology. All the recordings were done between 10-12 noon at ambient . SSR was measured by deep inspiration and the GSR was measured in the supine and standing response. of latency and amplitude of the sympathetic skin response and the percentage of decrease in galvanic skin was done. statistically significant delay in the latency and a reduction in the amplitude of sympathetic skin response was observed in diabetes patients. There was a lesser percentage of decrease in GSR in the diabetic patients. study shows that the SSR and GSR responses are significantly reduced in diabetic individuals and can be used as a tool in the detection of diabetic autonomic neuropathy.