Key result
Sympathetic skin response was absent at the foot in 66% and at the hand in 27.7% of diabetic patients with neuropathy, compared to 0% of normal controls.
Why the study?
Does sympathetic skin response assessment correlate with autonomic dysfunction in patients with diabetic neuropathy?
Population
47 diabetic patients with symptoms and clinical signs of peripheral neuropathy, and 24 normal control subjects
Comparison
Sympathetic skin response (SSR) assessment vs Normal control subjects
Design
Case-control
Authors
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May indicate autonomic neuropathy in diabetes; leaves open clinical utility pending prospective validation.
Case-Control (n=71)
Does sympathetic skin response assessment correlate with autonomic dysfunction in patients with diabetic neuropathy?
Absolute Event Rate: 66% vs 0%
The sympathetic skin response is frequently absent in diabetic neuropathy and correlates with cardiac autonomic dysfunction, suggesting it may be a useful adjunct in assessing autonomic involvement.
Soliven et al. (1987) conducted a case-control in Diabetic neuropathy (n=71). Diabetic neuropathy vs. Normal control subjects was evaluated on Absence of sympathetic skin response (SSR) at the foot. Sympathetic skin response was absent at the foot in 66% and at the hand in 27.7% of diabetic patients with neuropathy, compared to 0% of normal controls.
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