Key result
Novel adiposity indices, ABSI and BRI, were inversely and independently correlated with the ECG-derived Sokolow-Lyon Index in hypertensive patients (r = -0.296, p<0.001 and r = -0.238, p<0.01).
Why the study?
The relationship between novel anthropometric indices of central adiposity, such as ABSI and BRI, and electrocardiographic markers of left ventricular hypertrophy remains underexplored.
Do novel adiposity indices (ABSI and BRI) correlate with electrocardiographic evidence of LVH in hypertensive patients?
Cross-Sectional (n=274)
Do novel adiposity indices (ABSI and BRI) correlate with electrocardiographic evidence of LVH in hypertensive patients?
Effect estimate: r = -0.296 for ABSI, r = -0.238 for BRI
p-value: p=<0.001 for ABSI, <0.01 for BRI
Central adiposity indices (ABSI and BRI) are inversely associated with ECG-derived LVH voltages in hypertensive patients, suggesting that central obesity may attenuate ECG signals and obscure LVH detection.
ABSI/BRI may aid LVH detection beyond BMI; leaves open clinical utility pending validation studies.
Background/Objectives: Obesity is a key driver of cardiovascular disease (CVD), with central adiposity directly involved in adverse cardiac remodeling. Body mass index (BMI) is limited in capturing fat distribution and associated cardiovascular risk. Novel anthropometric indices, including A Body Shape Index (ABSI) and Body Roundness Index (BRI), may offer greater clinical value, but their relationship with electrocardiographic markers of left ventricular hypertrophy (LVH) remains underexplored. This study aims to assess the correlation between novel adiposity indices (ABSI and BRI) and electrocardiographic evidence of LVH, as measured by the Sokolow-Lyon Index (SLI), in individuals with arterial hypertension. Methods: 274 hypertensive patients were recruited, and BMI, ABSI, and BRI were calculated. LVH was assessed via SLI on 12-lead ECG. Participants were stratified by the SLI (≤35 mm vs. >35 mm) for statistical analyses. Results: Patients with a lower SLI showed significantly higher values of ABSI and BRI compared to those in higher SLI group, without differences in BMI. In the entire population, SLI was significantly and inversely correlated with both ABSI (r = −0.296, p < 0.001) and BRI (r = −0.238, p < 0.01), but not with BMI. Multivariate regression analysis confirmed ABSI (p = 0.013) and BRI (p = 0.038) as independent predictors of SLI, even after adjusting for age, blood pressure, renal function, and metabolic parameters. Conclusions: ABSI and BRI are inversely and independently associated with ECG-derived SLI in hypertensive individuals, suggesting that central adiposity may attenuate ECG voltages and obscure LVH detection. Incorporating novel adiposity indices into ECG interpretation may enhance diagnostic accuracy and risk stratification in obese and hypertensive populations. Longitudinal studies are needed to validate these findings and refine clinical algorithms.
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Geraci et al. (2025) conducted a cross-sectional in arterial hypertension (n=274). Novel adiposity indices (ABSI and BRI) was evaluated on Sokolow-Lyon Index (SLI) (r = -0.296 for ABSI, r = -0.238 for BRI, p=<0.001 for ABSI, <0.01 for BRI). Novel adiposity indices, ABSI and BRI, were inversely and independently correlated with the ECG-derived Sokolow-Lyon Index in hypertensive patients (r = -0.296, p<0.001 and r = -0.238, p<0.01).
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