Key result
Excess adiposity enhanced the effect of blood pressure on left ventricular growth, with a 1 SD increase in systolic BP increasing LVMI by 5.24 g/m in obese versus 1.61 g/m in lean participants (P<0.0001).
Why the study?
Does excess adiposity modify the relationship between blood pressure and left ventricular mass index?
Population
399 randomly recruited participants of African descent in South Africa from a general population with a high…
Comparison
Excess adiposity vs Normal adiposity
Design
Cross-sectional
Authors
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Supports weight management emphasis in obese hypertensives; leaves open whether reducing adiposity attenuates BP effects on LVMI.
Cross-Sectional (n=399)
Does excess adiposity modify the relationship between blood pressure and left ventricular mass index?
Absolute Event Rate: 5.24% vs 1.61%
p-value: p=< 0.0001
Excess adiposity exacerbates the hypertrophic effect of blood pressure on the left ventricle, suggesting that weight management is critical in preventing hypertensive heart disease.
Norton et al. (2009) conducted a cross-sectional in Hypertension and excess adiposity (n=399). Excess adiposity (increased waist circumference) vs. Normal waist circumference (lean) was evaluated on Increase in left ventricular mass index (LVMI) per 1 SD increase in systolic blood pressure (p=< 0.0001). Excess adiposity enhanced the effect of blood pressure on left ventricular growth, with a 1 SD increase in systolic BP increasing LVMI by 5.24 g/m in obese versus 1.61 g/m in lean participants (P<0.0001).
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