Key result
High sensitive C-reactive protein levels were and positively correlated with obesity indices, most strongly with waist circumference among Thai adults.
Why the study?
Obesity is related to cardiovascular risk, and hs-CRP predicts CVD risk and is elevated in inflammatory diseases, but its association with obesity among Thais required investigation.
Cross-Sectional (n=111)
No
High-sensitivity C-reactive protein levels positively correlate with multiple obesity indices in Thai adults, suggesting its potential utility as a biomarker for obesity-related cardiovascular risk.
Answers are grounded in this paper and cite their sources.
Does not warrant clinical use of hs-CRP for obesity assessment; hypothesis-generating correlation in Thai adults requires prospective validation.
Background: Obesity, a public health problem in many countries, was related to cardiovascular risk. High sensitive C-reactive protein (hs-CRP) was a predictor of cardiovascular disease (CVD) risk and elevated in inflammatory diseases. Objective: To investigate the association between hs-CRP and obesity among Thais. Materials and Methods: The present study was cross-sectional study. One hundred eleven adults were randomly recruited, and the anthropometric parameters were measured. Obesity indices, such as body mass index (BMI), body adiposity index (BAI), and waist to hip ratio (WHR) were calculated to estimate the obesity. Spearman’s correlation was used to evaluate the association between hs-CRP and obesity indices. The subjects were divided into three CVD risk groups according to hs-CRP levels. The hs-CRP less than 1 mg/L (n=31), the hs-CRP 1 to 3 mg/L (n=54), and the hs-CRP more than 3 mg/L (n=26) determined the low, intermediate, and high CVD risk groups, respectively. One-way ANOVA was used to determine the significant differences of obesity indices among the low, intermediate, and high CVD risk groups. Results: The present study showed a positive correlation between hs-CRP and obesity indices such as waist circumference (p<0.001, r=0.416), weight (p=0.001, r=0.311), hip circumference (p<0.001, r=0.376), WHR (p=0.024, r=0.214), BMI (p<0.001, r=0.383), and BAI (p<0.001, r=0.334). The results demonstrated that values of all obesity indices were elevated in intermediate and high CVD risk groups. BMI, waist circumference, and WHR expressed significant differences among low, intermediate, and high-risk groups (p<0.05). In addition, hs-CRP was significantly elevated in obese people compared with non-obese people. Conclusion: The hs-CRP positively correlated with obesity indices indicating the association between high level of hs-CRP and obesity.
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A 2020 study conducted a cross-sectional in Obesity (n=111). High sensitive C-reactive protein (hs-CRP) vs. Low hs-CRP levels was evaluated on Correlation between hs-CRP and waist circumference (r=0.416, p=<0.001). High sensitive C-reactive protein levels were and positively correlated with obesity indices, most strongly with waist circumference among Thai adults.
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