In healthy nonobese individuals, abdominal adiposity was associated with significantly higher hs-CRP levels compared to BMI-matched controls (1.96 vs. 1.53 mg/dl; P<0.01).
Case-Control (n=549)
Is abdominal adiposity associated with elevated hs-CRP independent of BMI in healthy nonobese people?
In nonobese individuals, moderate abdominal adiposity is associated with subclinical inflammation (elevated hs-CRP) independent of BMI.
Absolute Event Rate: 1.96% vs 1.53%
p-value: p=< 0.01
OBJECTIVE: There is debate over the most appropriate adiposity markers of obesity-associated health risks. We evaluated the relationship between fat distribution and high-sensitivity C-reactive protein (hs-CRP), independent of total adiposity. RESEARCH DESIGN AND METHODS: We studied 350 people with abdominal adiposity (waist-to-hip ratio WHR > or =0.9 in male and > or =0.85 in female subjects) and 199 control subjects (WHR 3 mg/dl). CONCLUSIONS: In nonobese people, moderate abdominal adiposity is associated with markers of subclinical inflammation independent of BMI.
Lapice et al. (Wed,) conducted a case-control in Abdominal adiposity in healthy nonobese people (n=549). Abdominal adiposity vs. Control subjects without abdominal adiposity (WHR <0.9 in males and <0.85 in females) was evaluated on high-sensitivity C-reactive protein (hs-CRP) (p=< 0.01). In healthy nonobese individuals, abdominal adiposity was associated with significantly higher hs-CRP levels compared to BMI-matched controls (1.96 vs. 1.53 mg/dl; P<0.01).