Key result
In healthy nonobese individuals, abdominal adiposity was associated with significantly higher hs-CRP levels compared to BMI-matched controls (1.96 vs. 1.53 mg/dl; P<0.01).
Why the study?
Is abdominal adiposity associated with elevated hs-CRP independent of BMI in healthy nonobese people?
Case-Control (n=549)
Is abdominal adiposity associated with elevated hs-CRP independent of BMI in healthy nonobese people?
In nonobese individuals, moderate abdominal adiposity is associated with subclinical inflammation (elevated hs-CRP) independent of BMI.
Answers are grounded in this paper and cite their sources.
Abdominal adiposity links to higher hs-CRP beyond BMI; leaves open causal role and WHR utility for inflammation risk in nonobese adults.
OBJECTIVE: There is debate over the most appropriate adiposity markers of obesity-associated health risks. We evaluated the relationship between fat distribution and high-sensitivity C-reactive protein (hs-CRP), independent of total adiposity. RESEARCH DESIGN AND METHODS: We studied 350 people with abdominal adiposity (waist-to-hip ratio [WHR] > or =0.9 in male and > or =0.85 in female subjects) and 199 control subjects (WHR <0.9 in male and <0.85 in female subjects) matched for BMI and age. We measured hs-CRP and major cardiovascular risk factors. RESULTS: Participants with abdominal adiposity had BMI similar to that in control subjects (24.8 +/- 2.5 vs. 24.7 +/- 2.2 kg/m(2), respectively), but significantly higher waist circumference (96.4 +/- 6.0 vs. 83.3 +/- 6.7 cm; P < 0.01) and WHR (1.07 +/- 0.08 vs. 0.85 +/- 0.05; P < 0.001). Compared with the control subjects, participants with abdominal adiposity had an adverse cardiovascular risk factor profile, significantly higher hs-CRP (1.96 +/- 2.60 vs. 1.53 +/- 1.74 mg/dl; P < 0.01), and a twofold prevalence of elevated CRP values (>3 mg/dl). CONCLUSIONS: In nonobese people, moderate abdominal adiposity is associated with markers of subclinical inflammation independent of BMI.
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Lapice et al. (2009) conducted a case-control in Abdominal adiposity in healthy nonobese people (n=549). Abdominal adiposity vs. Control subjects without abdominal adiposity (WHR <0.9 in males and <0.85 in females) was evaluated on high-sensitivity C-reactive protein (hs-CRP) (p=< 0.01). In healthy nonobese individuals, abdominal adiposity was associated with significantly higher hs-CRP levels compared to BMI-matched controls (1.96 vs. 1.53 mg/dl; P<0.01).
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