Assessment of adipokines relationships with cardiovascular risk markers in relation to body indices in normoglycemic males

Q: What are the key findings of this study?

Obesity in normoglycemic men was associated with higher hsCRP (4.48 vs 3.33 mg/L, p=0.0096), with waist-hip ratio (p=0.011) and adiponectin (p=0.049) independently predicting hsCRP.

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Normoglycemic healthy male individuals (obese and non-obese) (n=120). Intervention: Obesity indices (BMI, WHR, BFM, BF%) and serum adipokines (adiponectin, resistin) vs. Non-obese normoglycemic males. Primary outcome: High sensitivity C-reactive protein (hsCRP) levels (mg/L) (p=0.0096).

Q: What does this research mean for the field?

In normoglycemic men, obesity is associated with elevated hsCRP and reduced adiponectin levels, with waist-to-hip ratio and serum adiponectin serving as independent predictors of hsCRP. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Syed Shahid Habib; Khlalid A Al Regaeiy; Laila M AL-Dokhi

doi:10.12669/pjms.291.2913

January 17, 2013Pakistan Journal of Medical SciencesOpen Access

Assessment of adipokines relationships with cardiovascular risk markers in relation to body indices in normoglycemic males

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Key result

Obesity in normoglycemic men is linked to ~1.2 mg/L higher hsCRP levels.

P=0.0096
n=120

Why the study?

The phenotypic relationships among obesity indices, resistin, adiponectin, and cardiovascular risk markers in normoglycemic healthy individuals required evaluation.

Are obesity indices and serum adipokines (adiponectin and resistin) associated with and independent predictors of hsCRP levels in normoglycemic healthy males?

Key Points

To evaluate the relationship between obesity indices, adipokines (resistin and adiponectin), and cardiovascular risk markers in normoglycemic healthy individuals.
Conducted a cross-sectional study in the Department of Physiology at King Saud University, Riyadh.
Enrolled 120 normoglycemic male subjects.
Assessed body composition, glucose, HbA1c, lipids, lipoprotein(a), resistin, adiponectin, and high-sensitivity C-reactive protein (hsCRP).
Body mass index (r=0.326, p<0.001), body fat mass (r=0.377, p<0.001), body fat percentage (r=0.326, p<0.001), waist-hip ratio (r=0.402, p<0.001), and basal insulin (r=0.217, p=0.018) positively correlated with hsCRP, whereas serum adiponectin negatively correlated with hsCRP (r=0.189, p=0.0391).
Obese subjects had significantly higher hsCRP (4.48±2.74 vs 3.33±2.00 mg/L, p=0.0096) and lower adiponectin levels compared to non-obese subjects (p=0.0551).
Multiple regression analysis revealed that waist-hip ratio (Beta=0.669, 95% CI 5.474 to 41.305, p=0.011) and adiponectin (Beta=-0.251, 95% CI -0.021 to -0.001, p=0.049) were independent predictors of hsCRP.

Study Design

Type

Cross-Sectional (n=120)

Multicenter

No

Structured PICO

Are obesity indices and serum adipokines (adiponectin and resistin) associated with and independent predictors of hsCRP levels in normoglycemic healthy males?

P

Population

120 normoglycemic healthy male adults (mean age 40.16 years, range 21-71, 0% female) evaluated in a cross-sectional study in Saudi Arabia.

E

Exposure

Exposure to obesity / elevated adiposity indices (body mass index [BMI], body fat mass [BFM], body fat percentage [BF%], waist-hip ratio [WHR]) and circulating adipokines (adiponectin, resistin)

C

Comparator

Non-obese normoglycemic male subjects

O

Outcome

Serum high-sensitivity C-reactive protein (hsCRP) levels (mg/L) and its phenotypic relationship / independent prediction by obesity indices and adipokinessurrogate

Main Result

Absolute Event Rate: 4.48% vs 3.33%

p-value: p=0.0096

In normoglycemic Saudi men, visceral adiposity (measured by waist-hip ratio) and lower serum adiponectin levels are independent predictors of elevated hsCRP, highlighting subclinical inflammation in obesity even in the absence of dysglycemia.

Limitations

Cross-sectional design precludes strong causative conclusions
Relatively homogenous population with lower CVD risks because all subjects were normoglycemic
Included only male subjects from a single ethnic population (Saudi), limiting generalizability to women and other ethnic groups
Cross-sectional design unable to provide a strong causative conclusion
Relatively homogenous subjects with lower CVD risks because all were normoglycemic
Included only male subjects, requiring caution when applying conclusions to the general population, women, and other ethnic groups

Implication

Supports visceral adiposity–inflammation link in normoglycemic men; hypothesis-generating, prospective studies needed before clinical adoption.

Abstract

OBJECTIVES: To evaluate the phenotypic relationship between obesity indices, resistin, adiponectin and cardiovascular risk markers in normoglycemic healthy individuals. METHODOLOGY: This cross-sectional study was conducted in the Department of Physiology College of Medicine, King Saud University, Riyadh. A total of 120 male subjects were selected for the study. All subjects underwent analysis of body composition, glucose, glycosylated hemoglobin (HbA1c), lipids, adiponectin, resistin, lipoprotein(a) and high sensitivity C reactive protein (hsCRP). RESULTS: Body mass index (BMI) (r=0.326, p < 0.001), body fat mass (BFM) (r=0.377, p < 0.001), body fat percentage (BF%) (r=0.326, p < 0.001), waist hip ratio (WHR) (r=0.402, p < 0.001) and basal Insulin levels (r=0.217, p=0.018) were positively correlated with hsCRP. However, serum adiponectin levels (r=0.189, p=0.0391) were negatively correlated with hsCRP. Adiponectin levels were significantly lower in obese compared to non obese subjects (p=0.0551). Keeping hsCRP as dependant variable we observed that WHR, BFM, BF%, BMI and adiponectin were significant predictors in univariate analysis. In multiple regression analysis WHR and adiponectin were independent predictors of hsCRP. CONCLUSION: Obese individuals have significantly higher levels of hsCRP levels and lower adiponectin levels than non obese subjects. Serum adiponectin levels and WHR are independant predictors of hsCRP levels in normoglycemic subjects.

Discussion

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Cite This Study

Habib et al. (2013) conducted a cross-sectional in Normoglycemic healthy male individuals (obese and non-obese) (n=120). Obesity indices (BMI, WHR, BFM, BF%) and serum adipokines (adiponectin, resistin) vs. Non-obese normoglycemic males was evaluated on High sensitivity C-reactive protein (hsCRP) levels (mg/L) (p=0.0096). Obesity in normoglycemic men was associated with higher hsCRP (4.48 vs 3.33 mg/L, p=0.0096), with waist-hip ratio (p=0.011) and adiponectin (p=0.049) independently predicting hsCRP.

synapsesocial.com/papers/6ae1687bf9baa8dfaf818719 https://doi.org/10.12669/pjms.291.2913

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Assessment of adipokines relationships with cardiovascular risk markers in relation to body indices in normoglycemic males

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Assessment of adipokines relationships with cardiovascular risk markers in relation to body indices in normoglycemic males

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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