Key result
Early essential hypertension is linked to increased mineralocorticoid secretion and reduced aldosterone clearance.
Answers are grounded in this paper and cite their sources.
Patients with benign essential hypertension in the early uncomplicated stage show several deviations from normal in their renal and adrenal hormonal systems. Levels of plasma aldosterone and progesterone and the secretion rate of 18-hydroxy-11-deoxycorticosterone are shown to be increased, and the metabolic clearance rate of aldosterone is shown to be decreased in these patients. Also, in vitro, the plasma, with added homologous renin, generated angiotensin at rates much higher than normal. Conflicting evidence is presented on plasma aldosterone measurements, including age-dependent decreases in plasma renin and aldosterone. The significance of these findings in pathogenesis of essential hypertension is discussed.
No takes yet. Share an insight, caveat, or question.
Mohinder P. Sambhi (1973) conducted a review in Benign essential hypertension in the early uncomplicated stage. Early uncomplicated benign essential hypertension vs. Normal controls was evaluated on Renal and adrenal hormonal levels and clearance/generation rates (aldosterone, progesterone, 18-hydroxy-11-deoxycorticosterone, renin, angiotensin). Early uncomplicated essential hypertension is associated with increased plasma aldosterone, progesterone, 18-OH-DOC secretion, and in vitro angiotensin generation, alongside decreased aldosterone clearance.
Synapse has enriched 10 related papers. Consider them for comparative context: