What question did this study set out to answer?

To investigate the therapeutic efficacy and protective mechanisms of calanus oil against isoproterenol-induced pathological cardiac hypertrophy.

January 1, 2023Ultrastructural Pathology

Calanus oil attenuates isoproterenol-induced cardiac hypertrophy by regulating myocardial remodeling and oxidative stress

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Authors

SAShrook Y. AbdellatifAin Shams University NFNagui Hassan FaresAin Shams University SESamar H. ElsharkawyCairo University

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Implication

Preclinical study demonstrates calanus oil reduces isoproterenol-induced cardiac hypertrophy and oxidative stress in rodents, indicating its therapeutic potential for heart remodeling.

Key Points

To investigate the therapeutic efficacy and protective mechanisms of calanus oil against isoproterenol-induced pathological cardiac hypertrophy.
Induced cardiac hypertrophy via daily subcutaneous injections of isoproterenol (5 mg/kg body weight) for 14 consecutive days.
Administered calanus oil orally at a dosage of 400 mg/kg daily for 4 weeks.
Assessed cardiac structure and function via echocardiography, alongside morphometric, histopathological, ultrastructural, and serum biochemical evaluations (LDH, CK-MB, MDA, and TAC).
Calanus oil significantly attenuated structural and functional abnormalities on echocardiography and lowered relative heart weight.
Treatment markedly suppressed elevated cardiac injury enzymes (LDH and CK-MB) and reduced the lipid peroxidation marker MDA while boosting total antioxidant capacity (TAC).
Histological and ultrastructural evaluations showed preserved myocardial tissue integrity and significant inhibition of interstitial collagen deposition.

Cite This Study

Abdellatif et al. (2023) studied this question.

synapsesocial.com/papers/6a7c97801c02bd024a6ee218 https://doi.org/10.1080/01913123.2022.2163016

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Implication

Preclinical study demonstrates calanus oil reduces isoproterenol-induced cardiac hypertrophy and oxidative stress in rodents, indicating its therapeutic potential for heart remodeling.

Calanus oil attenuates isoproterenol-induced cardiac hypertrophy by regulating myocardial remodeling and oxidative stress

Discussion

Member takes

Implication

Key Points

Cite This Study

Calanus oil attenuates isoproterenol-induced cardiac hypertrophy by regulating myocardial remodeling and oxidative stress

Discussion

Member takes

Implication

Key Points

Cite This Study

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