Event Rates and Risk Factors for Recurrent Cardiovascular Events and Mortality in a Contemporary Post Acute Coronary Syndrome Population Representing 239 234 Patients During 2005 to 2018 in the United States

Figures

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  Figure 1. Consort diagram for patient selection. Patients with an ACS hospitalization during January 1, 2005 to December 30, 2018 were initially selected. Sequential application of the study inclusion and exclusion criteria resulted in a final study population of N=239 234. ACS indicates acute coronary syndrome; and NDI, National Death Index.

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  Figure 2. Event rates and instantaneous risk over time for the primary and individual end points. Shown is the cumulative incidence of the primary end point (first occurrence of nonfatal MI, nonfatal ischemic stroke, or CV death) and individual end points (represented by components of the composite). The KM rates for the primary end point at 1, 3, and 5 years were 14.5% (95% CI, 14.3%–14.6%; P<0.001), 25.2% (95% CI, 25.0%–25.5%; P<0.001), and 33.4% (95% CI, 33.1%–33.7%; P<0.001), respectively. The instantaneous risks (annualized) for the primary end point at 0, 1, and 3 years were 40.9%, 6.7%, and 6.4%, respectively. Below the graphs capturing the cumulative incidence of the primary and individual end points are data on the number of patients at risk of experiencing the corresponding end point. CV indicates cardiovascular; IS, ischemic stroke; KM, Kaplan‐Meier; and MI, myocardial infarction.

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  Figure 3. Event rates for the primary and individual end points by type of index acute coronary syndrome and use of revascularization. Shown is the cumulative incidence of the primary end point (first occurrence of nonfatal MI, nonfatal ischemic stroke, or CV death) and individual end points (represented by components of the composite) by index ACS (MI/UA and revascularization status). Below each graph are data on the number of patients in each index ACS subgroup who are at risk of experiencing the corresponding end point. ACS indicates acute coronary syndrome; CV, cardiovascular; IS, ischemic stroke; MI, myocardial infarction; Revasc, revascularization; and UA, unstable angina.

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  Figure 4. Event rates for the primary and individual end points by categories of TIMI risk score for secondary prevention. Shown is the cumulative incidence of the primary end point (first occurrence of nonfatal MI, nonfatal ischemic stroke, or CV death) and individual end points (represented by components of the composite) by TRS 2oP categories. Below each graph are data on the number of patients in each TRS 2oP category who are at risk of experiencing the corresponding end point. CV indicates cardiovascular; IS, ischemic stroke; MI, myocardial infarction; TIMI, Thrombolysis In Myocardial Infarction; and TRS 2oP, Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention.

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  Figure 5. Event rates for the primary and individual end points by categories of TIMI risk score for secondary prevention and use of revascularization. Shown is the cumulative incidence of the primary end point (first occurrence of nonfatal MI, nonfatal ischemic stroke, or CV death) and individual end points (represented by components of the composite) by TRS 2oP categories and use of revascularization. Below each graph are data on the number of patients in each TRS 2oP category with or without revascularization who are at risk of experiencing the corresponding end point. CV indicates cardiovascular; IS, ischemic stroke; MI, myocardial infarction; Revasc, revascularization; TIMI, Thrombolysis In Myocardial Infarction; and TRS 2oP, Thrombolysis In Myocardial Infarction Risk Score for Secondary Prevention.