Key result
Intravenous hydration and oral levothyroxine therapy successfully resolved severe rhabdomyolysis and normalized creatine kinase levels in a 34-year-old female with untreated hypothyroidism.
Case Report (n=1)
Hypothyroidism should be considered in the differential diagnosis of rhabdomyolysis, especially when other common causes are ruled out.
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May prompt thyroid testing in rhabdomyolysis; Level 5 evidence leaves open prospective validation.
Rhabdomyolysis is a condition caused by muscle breakdown. It can be usually associated with pain, weakness, and elevated creatinine kinase levels on laboratory testing. There are various triggers, some of which can include trauma, dehydration, infections, and, as in this case, autoimmune disorders. Here, we present a case of a patient with worsening muscle pain who was found to have elevated creatinine kinase levels and undiagnosed hypothyroidism, with symptoms improving with intravenous hydration and thyroid supplementation.
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Syed et al. (2023) conducted a case report in Hypothyroidism-induced rhabdomyolysis (n=1). Levothyroxine and intravenous fluids was evaluated on Resolution of rhabdomyolysis and normalization of creatine kinase levels. Intravenous hydration and oral levothyroxine therapy successfully resolved severe rhabdomyolysis and normalized creatine kinase levels in a 34-year-old female with untreated hypothyroidism.
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