Why the study?
Does telmisartan reduce ocular inflammation in a mouse model of endotoxin-induced uveitis?
Population
C57BL/6 mice with endotoxin-induced uveitis induced by a single intraperitoneal injection of 150 mug…
Comparison
Telmisartan 10 mg/kg daily administered… vs Vehicle treatment
Design
Preclinical
Follow-up
24 hours after LPS administration
Authors
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May extend ARB anti-inflammatory effects to uveitis models; leaves open translation to human disease.
Does telmisartan reduce ocular inflammation in a mouse model of endotoxin-induced uveitis?
Blockade of the angiotensin II type 1 receptor with telmisartan significantly reduces ocular inflammation in a murine model of endotoxin-induced uveitis.
Nagai et al. (2005) studied this question.
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