Why the study?
Does a decoy handle-region peptide (HRP) reduce ocular inflammation in a rat model of endotoxin-induced uveitis?
Population
Long-Evans rats with endotoxin-induced uveitis induced by a single intraperitoneal injection of 100 microg…
Comparison
Decoy handle-region peptide administered… vs Control EIU rats (implied)
Design
Preclinical
Follow-up
24 hours
Authors
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HRP may attenuate ocular inflammation in experimental uveitis; leaves open translation to human disease pending clinical studies.
Does a decoy handle-region peptide (HRP) reduce ocular inflammation in a rat model of endotoxin-induced uveitis?
Inhibition of nonproteolytic activation of prorenin using a decoy handle-region peptide suppresses ocular inflammation in a rat model of endotoxin-induced uveitis.
Satofuka et al. (2006) studied this question.
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