Why the study?
Low birthweight has been associated with increased adult cardiovascular disease, but early markers like endothelial dysfunction and arterial elasticity loss in children are not well characterized.
Does a history of low birthweight associate with impaired endothelial function and increased arterial stiffness in healthy prepubertal children?
Population
44 healthy prepubertal children aged 9±1.3 years including 22 with low birthweight
Comparison
Children with low birthweight vs normal-birthweight controls
Design
Cross-sectional study
Authors
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May indicate early vascular changes in LBW children; leaves open whether these markers predict adult CVD or merit intervention.
Does a history of low birthweight associate with impaired endothelial function and increased arterial stiffness in healthy prepubertal children?
Children with a history of low birthweight exhibit early markers of vascular compromise, including impaired endothelial function and increased carotid stiffness, which may predispose them to adult cardiovascular disease.
Martin et al. (2000) studied this question.
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