Why the study?
Does low birth weight impair endothelial function in fit young adults?
Population
39 fit 19-20 year old subjects randomly selected from the 1975-7 cohort of the Cardiff Births Survey, with…
Comparison
Low birth weight (< 2.5 kg) vs Normal birth weight (3.0-3.8 kg)
Design
Cohort, Blind to the investigators throughout the study
Authors
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Supports fetal origins of endothelial dysfunction; hypothesis-generating and should not yet change practice.
Does low birth weight impair endothelial function in fit young adults?
Low birth weight is associated with impaired endothelial function in young adulthood, suggesting a fetal origin for cardiovascular risk factors.
Jonathan Goodfellow (1998) studied this question.
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